Sunday 18th January 2015
“We’re now at the point where it’s easy to extend the lifespan of a mouse. That’s not the question any more, it’s can we do this in humans? And I don’t see any reason why we can’t,” says David Sinclair, a researcher based at Harvard.
Reason for optimism comes after several different approaches have yielded promising results. Some existing drugs, such as the diabetes drug metformin, have serendipitously turned out to display age-defying effects, for example. Several drugs are in development that mimic the mechanisms that cause lab animals fed carefully calorie-restricted diets to live longer. Others copy the effects of genes that occur in long-lived people.
Tuesday 29th December 2015
Anti-Aging Research: Metformin
The SENS Research Foundation, Google Calico and Human Longevity, Inc. are racing to churn out the most promising anti-aging and longevity research
“There is an increasing number of people realizing that the concept of anti-aging medicine that actually works is going to be the biggest industry that ever existed by some huge margin, and that it just might be foreseeable,” Aubrey de Grey, founder of SENS and the Methuselah Foundation (which awards grants to for anti-aging research) told the Guardian in January 2015.
One of the most promising avenues of research centers around Metformin, a diabetes medication thought to prolong life.
This year, the FDA approved the first human clinical trials for an anti-aging medication. Researchers will test preliminary mouse studies that suggest Metformin could increase average lifespan by nearly 40 percent.
Wednesday 20th January 2016
Anti-Aging Pill: Metformin
Metformin is a generic diabetes drug that costs only a few cents a dose.
Metformin reduces blood sugar and works on multiple pathways involved in cell growth, inflammation and metabolism — all of which constitute the major pillars of aging.
Epidemiological studies suggest that metformin reduces the risk of cancer and dementia.
Wednesday 20th January 2016
TAME (Targeting Aging with Metformin) to be Tested on 3,000 Volunteers
To most of the scientific community, “anti-aging” is a dirty word.
A medical field historically associated with charlatans and quacks, scientists have strictly restricted the quest for a “longevity pill” to basic research. The paradigm is simple and one-toned: working on model organisms by manipulating different genes and proteins, scientists slowly tease out the molecular mechanisms that lead to — and reverse — signs of aging, with no guarantee that they’ll work in humans.
But it’s been a fruitful search: multiple drug candidates, many already on the market for immune or psychiatric disorders, have consistently delayed age-associated diseases and stretched the lifespan of fruit flies, roundworms and mice.
Yet human trials have been far beyond reach — without the FDA acknowledging “aging” as a legitimate target for drug development, researchers have had no way of pitching clinical trials to the regulatory agency.
Last year, the FDA green lighted an audacious proposal that seeks to test in 3,000 volunteers a drug that — based on animal studies — could extend human lifespan by up to 40 percent and decrease chances of getting age-related diseases.
The double-blind, multi-centered trial, Targeting Aging with Metformin (TAME), is the first that pushes aging as a bona fide disease — one that may eventually be tamed with drugs.
Metformin seems to fit the bill of a longevity drug. But it was the chemical’s two other perks that made it a winner to the TAME team.
First, it’s very safe. When taken as prescribed, the drug has few side effects, and those that do occur are well documented.
Second, is that in addition to extending lifespan, it also extends healthspan — the number of years that an organism remains healthy, even in old age.
“We think this is a groundbreaking, perhaps paradigm-shifting trial,” said Dr. Steven Austad, scientific director of the American Federation for Aging Research (AFAR). – Shelly Fan
Friday 29th July 2016
ANALYSIS OF NOTABLE BRIDGE 1 LONGEVITY OPTIONS
Metformin releases more oxygen into cells, which is believed to result in longevity benefits.
It is a calorie restriction mimetic.
Calorie restriction is proven to extend the lives of a variety of organisms from yeast cells to monkeys. Metformin activates this response without us having to go through the ordeal of starving ourselves.
Metformin has extended the lives of lab mice by as much as 40% but unfortunately this doesn’t mean it will translate to a 40% increase in human life expectancy. It just doesn’t scale like that.
Aubrey de Grey believes that life extension gains in nominal years for humans will be limited because calorie restriction has considerably less benefits proportionally in long lived species than short lived species.
Upcoming Metformin FDA Trials known as TAME (Targeting Aging with Metformin) will be conducted on 3,000 people aged 70 to 80.
This trial is a milestone, as for the first time ever, the FDA are engaging in anti-aging medicine.
Up until now, the FDA has refused to engage with attempts to treat aging. This has been very damaging as it’s had a chilling effect on the medical community’s interest in developing drugs.
Metformin is commonly available and has been around for a long time (it was invented in 1959). It is very cheap at around 6 cents per pill. Some people experience side effects but on balance these are considered relatively minimal.
Overall, Metformin’s positive impact is likely to be a few years of life extension at best, but it still might be a good option until more powerful alternatives become available as we approach Bridge 2 in the 2020s and 2030s.
The FDA trials start this year. Results and a recommended course of action will become more apparent in 5 or 6 years when we can see if it helped delay death and prevent diseases.
CONCLUSION: BRIDGE 1 ANTI-AGING STRATEGIES
BEST OF THE CURRENT BUNCH
ANTIOXIDNTS & GENERAL HEALTH
MAINTAINANCE OF THE CELL’S MITOCHONDRIA
MAINTAINANCE OF THE CELL MEMBRANE
ONES TO WATCH (MOST PROMISING)
Near – Medium Term
Nicotinamide Riboside (NAD+)
Medium – Long Term
Stem Cell Therapy