Saturday 11th January 2015
Life Extension: Resveratrol Found to Activate Response at 1,000x Lower Doses
The first studies of resveratrol in the early 2000s had suggested that it exerts some of its positive effects on health by activating SIRT1, also thought to be a longevity gene. But SIRT1’s role in mediating resveratrol’s reported health-boosting effects has been questioned lately.
The team’s experiments showed, however, that the TyrRS-PARP-1 pathway can be measurably activated by much lower doses of resveratrol — as much as 1,000 times lower — than were used in some of the more celebrated prior studies, including those focused on SIRT1. “Based on these results, it is conceivable that moderate consumption of a couple glasses of red wine (rich in resveratrol) would give a person enough resveratrol to evoke a protective effect via this pathway,” Sajish said.
Resveratrol is a compound produced in grapes, cacao beans, Japanese knotweed and some other plants in response to stresses including infection, drought and ultraviolet radiation – KurzweilAI
Sunday 18th January 2015
“We’re now at the point where it’s easy to extend the lifespan of a mouse. That’s not the question any more, it’s can we do this in humans? And I don’t see any reason why we can’t,” says David Sinclair, a researcher based at Harvard.
Some drugs set to be tested in humans are compounds inspired by resveratrol, a compound found in red wine. Some scientists believe it is behind the “French paradox” that French people have a low incidence of heart disease despite eating comparatively rich diets.
In 2003, Sinclair published evidence that high doses of resveratrol extend the healthy lives of yeast cells. After Sirtris, a company co-founded by Sinclair, showed that resveratrol-inspired compounds had favourable effects in mice, it was bought by drug giant GlaxoSmithKline for $720m in 2008. Although development has proved more complicated than first thought, GSK is planning a large clinical trial this year, says Sinclair. He is now working on another drug that has a different way of activating the same pathway – Zoe Corbyn
Wednesday 11th February 2015
Ashok K. Shetty, Ph.D., a professor in the department of molecular and cellular medicine and director of neurosciences at the Institute for Regenerative Medicine, has been studying the potential benefit of resveratrol, an antioxidant that is found in the skin of red grapes, as well as in red wine, peanuts, and some berries.
Resveratrol has been widely touted for its potential to prevent heart disease, but Dr. Shetty and a team that includes other researchers from the health science center believe it also has positive effects on the hippocampus, an area of the brain that is critical to functions such as memory, learning, and mood.
Because both humans and animals show a decline in cognitive capacity after middle age, the findings may have implications for treating memory loss in the elderly. Resveratrol may even be able to help people afflicted with severe neurodegenerative conditions such as Alzheimer’s disease.
Dr. Shetty and his research team members reported that treatment with resveratrol had apparent benefits in terms of learning, memory, and mood function in aged rats.”The results of the study were striking,” according to Dr. Shetty. “They indicated that for the control rats who did not receive resveratrol, spatial learning ability was largely maintained but ability to make new spatial memories significantly declined between 22 and 25 months. By contrast, both spatial learning and memory improved in the resveratrol-treated rats.”
“The study provides novel evidence that resveratrol treatment in late middle age can help improve memory and mood function in old age,” said Dr. Shetty. – GeneticEngineering & Biotechnology News
Monday 23rd May 2016
Pterostilbene is an Extra-Potent Version of Resveratrol
NAD boosters might work synergistically with supplements like resveratrol to help reinvigorate mitochondria and ward off diseases of aging.
Elysium is banking on this potential synergy—its NR-containing supplement includes a resveratrol-like substance called pterostilbene (pronounced tero-STILL-bean), which is found in blueberries and grapes.
Why pterostilbene instead of resveratrol?
While resveratrol has hogged the anti-aging spotlight over the past decade, unsung researchers have quietly shown that pterostilbene is a kind of extra-potent version of resveratrol.
The pterostilbene molecule is nearly identical to resveratrol’s except for a couple of differences that make it more “bioavailable” (animal studies indicate that about four times as much ingested pterostilbene gets into the bloodstream as resveratrol).
Test-tube and rodent studies also suggest that pterostilbene is more potent than resveratrol when it comes to improving brain function, warding off various kinds of cancer and preventing heart disease.
Elysium isn’t the only pterostilbene vendor. In fact, ChromaDex also offers pterostilbene for supplements separately from Niagen. – David Stipp
Friday 29th July 2016
RAY KURZWEIL’S BRIDGE 1 STRATEGY
One of the most aggressive approaches to surviving Bridge 1 is Ray Kurzweil’s supplement regime.
In 2012 Ray stated that he takes about 150 pills per day (which is 70-80 different things) as part of his quest to get to “Bridge 2”.
By 2015 he had managed to get this down to 100 pills per day by finding more bio-available forms.
This costs him a few thousand dollars per year, although he says it’s not necessary for everyone. “It’s not one size fits all. A healthy 30-year-old might just need basic supplements”.
Kurzweil has been accused of being “reckless” with his level of supplementation, which he refutes:
I monitor my body regularly. I’m not just flying without instrumentation. Being an engineer, I like data and I monitor 50 or 60 different blood levels every few months, and I’m constantly fine-tuning my program.
All of my blood levels are ideal. I scan my arteries to see if I have plaque buildup, and I have no atherosclerosis. I come out younger on biological aging tests.
So far, so good. But this program is not designed to last a very long time. This program is what we call bridge one. The goal is to get to bridge two: the biotechnology revolution, where we can reprogram biology away from disease.
Below is a list of some of the supplements Ray has previously mentioned taking:
For Anti-Oxidation and General Health
- Comprehensive multi-vitamin
- Coenzyme Q10
- Grapeseed extract
- Bilberry extract
- Linoleic acid
- B12 shots
ANALYSIS OF NOTABLE BRIDGE 1 LONGEVITY OPTIONS
CALORIE RESTRICTION MIMETICS
Resveratrol is perhaps the most famous antioxidant with perceived longevity benefits due to its presence in red wine.
It’s thought that resveratrol may help maintain DNA, protect cells, and supporting mitochondrial function.
Health and longevity improvements have been observed in mice and it’s possible that these carry over to humans. However, clinical evidence of its benefits is lacking, although research is ongoing.
Along with Metformin and Rapamycin, it is a known calorie restrictive mimetic which is thought to extend life by tricking the body into believing it’s running out of energy. This causes it to put more effort into long-term survival.
Supplementing resveratrol may be beneficial but better results need to be demonstrated. – Lee Banfield, Exploring Anti-Aging Strategies