Senolytics

Wednesday 18th March 2015

Drugs That Dramatically Increase Healthy Lifespan Discovered

A research team has identified a new class of drugs that in animal models dramatically slows the aging process, alleviating symptoms of frailty, improving cardiac function, and extending a healthy lifespan.

They found two drugs — the cancer drug dasatinib (sold under the trade name Sprycel) and quercetin, a natural compound found in many fruits, vegetables, leaves and grains and also sold as a supplement that acts as an antihistamine and anti-inflammatory — can kill senescent cells. These are cells that have stopped dividing and accumulate with age, accelerating the aging process.

The scientists coined the term “senolytics for this new class of drugs.

“We view this study as a big first step toward developing treatments that can be given safely to patients to extend healthspan or to treat age-related diseases and disorders,” said TSRI Professor Paul Robbins, PhD – Kurzweil Accelerating Intelligence

 

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